Search results for "in fact"

showing 10 items of 23 documents

Fiscality of couples in fact

2019

[ES] Las parejas de hecho son una unión alternativa al matrimonio y, como tal, el ordenamiento les dedica un régimen jurídico. El presente estudio trata sobre la fiscalidad que rodea a estas uniones partiendo siempre de su situación patrimonial y los acuerdos alcanzados entre los convivientes. Se analiza el encaje dentro del IRPF de la pareja de hecho y la aplicación de las circunstancias personales y familiares a los convivientes. Asimismo, se tratará la aportación de éstos a la comunidad de bienes formada por ambos y la adquisición de bienes una vez constituida la misma. Todo ello desde la aplicación de los impuestos que gravan la transmisión o adquisición de bienes, ya sea de forma onero…

:CIENCIAS JURÍDICAS [UNESCO]Couples in factCommunity of goodsUNESCO::CIENCIAS JURÍDICASDisolución de la comunidadDissolution of the communityPareja de hechoECONOMIA FINANCIERA Y CONTABILIDADMínimo por descendienteComunidad de bienesMinimum by descendant
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Taxation of the family with children in charge

2020

[EN] The family institution is fundamental in every society. The family formed within the marriage or couple in fact deserves the economic and social protection on the part of the public Powers. The present study deals with the taxation that surrounds these institutions when there are minors in their charge. Their taxation will be analyzed within the personal income tax and the application of personal and family circumstances to them. First, the taxation of Large Families will be studied since they have the largest number of minors under their protection, then families made up of married couples and couples in fact who have minors in their care and, finally, we will address taxation in the …

:CIENCIAS JURÍDICAS [UNESCO]Couples in factImpuestosParejas de hechoMenores de edadMinorsTaxationMatrimonioUNESCO::CIENCIAS JURÍDICASFamiliaFamilyECONOMIA FINANCIERA Y CONTABILIDADMarriage
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Anulación del privacy shield en las transferencias internacionales de datos : ¿presenciamos un desplazamiento fáctico de la responsabilidad?

2021

This study provides a comprehensive analysis of international transfers of personal data to third countries or international organizations due to new privacy regulation. More specifically, it analyzes the effects on this regulatory scheme of the annulment of the Privacy Shield in the transatlantic information movements between the European Union and the United States and how this implies, in fact, a transfer of responsibility to the controller

:CIENCIAS JURÍDICAS [UNESCO]international transfers2070-8157 22082 Revista Boliviana de Derecho 565487 2021 31 7730066 Anulación del privacy shield en las transferencias internacionales de datos ¿presenciamos un desplazamiento fáctico de la responsabilidad? Rodríguez AyusoEE. UU.US 476 503RGPDtransferencias internacionalesPrivacyUNESCO::CIENCIAS JURÍDICASin factit analyzes the effects on this regulatory scheme of the annulment of the Privacy Shield in the transatlantic information movements between the European Union and the United States and how this impliesJuan Francisco This study provides a comprehensive analysis of international transfers of personal data to third countries or international organizations due to new privacy regulation. More specificallya transfer of responsibility to the controller Dato personalGDPRUEEU
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Italian assisted negotiation: an additional tool to settle matrimonial property regime cases

2021

The assisted negotiation procedure highlighted the need to distinguish the various forms of justice in view to obtaining decisions that can effectively satisfy the interests of the family. In fact the agreements who discipline the family conflicts attributes a central role to the will of the couple in the collaborative search for suitable solutions for the management of the crisis of the emotional bond.

:CIENCIAS JURÍDICAS [UNESCO]métodos alternativos de solución de conflictos. 164 179Negociación asistidaUNESCO::CIENCIAS JURÍDICASprenuptial agreementsfamily conflictsconflictos familiaresManuela The assisted negotiation procedure highlighted the need to distinguish the various forms of justice in view to obtaining decisions that can effectively satisfy the interests of the family. In fact the agreements who discipline the family conflicts attributes a central role to the will of the couple in the collaborative search for suitable solutions for the management of the crisis of the emotional bond. Assisted negotiationalternative dispute resolution.2386-4567 22661 Actualidad jurídica iberoamericana 587897 2021 15 8113555 Italian assisted negotiation an additional tool to settle matrimonial property regime cases Giobbiacuerdos prematrimoniales
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Getting married or entering into a partnership : the patrimonial issues of choice in french law

2021

In French law, there are only two models of couples between which a choice is really possible to organize their patrimonial relationships: partnership or marriage. But, if the couple intends to organize a transfer of assets between companions both during the union and in case of death, it is definitely marriage that offers more possibilities than partnership. Often, young French couples, who do not wish to marry, either not at the begining of their relationship or not at all, have the idea that, if marriage organizes a legal protection of the couple, the partners have the possibility to provide conventionally equivalent protection. In fact, this idea is wrong.

:CIENCIAS JURÍDICAS [UNESCO]partnership or marriage. But [there are only two models of couples between which a choice is really possible to organize their patrimonial relationships]have the idea thatlegal protectionreserva 14 23reserveprotección legalif the couple intends to organize a transfer of assets between companions both during the union and in case of deathpartnership [this idea is wrong. Marriage]transmissiontransmisión2386-4567 22661 Actualidad jurídica iberoamericana 587897 2021 15 8113545 Getting married or entering into a partnership the patrimonial issues of choice in french law Berryyoung French couplesUNESCO::CIENCIAS JURÍDICASMatrimoniounión de hechoElsa In French laweither not at the begining of their relationship or not at allthere are only two models of couples between which a choice is really possible to organize their patrimonial relationships: partnership or marriage. Butwho do not wish to marryif marriage organizes a legal protection of the couplethis idea is wrong. Marriage: partnershipit is definitely marriage that offers more possibilities than partnership. Oftenthe partners have the possibility to provide conventionally equivalent protection. In fact
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Prophylaxis In Congenital Factor VII Deficiency, Indications, Efficacy and Safety: Results of the STER

2010

Abstract Abstract 665 Introduction Prophylaxis is considered a difficult endeavour in FVII deficiency, especially because of the very short FVII zymogen and FVIIa half-lives, mainly in childhood. The Seven Treatment Evaluation Registry (STER, www.targetseven.org) is a prospective observational, multi-centre, web-based registry concerned with the evaluation of treatments for spontaneous bleeding episodes, surgery and prophylaxis in patients with FVII deficiency. As regards prophylaxis, STER provides the frame for a structured and detailed data capture aiming at: a) identifying patients in whom prophylaxis is advisable, b) defining clinical settings in which prophylaxis is necessary and c) de…

Gastrointestinal bleedingPediatricsmedicine.medical_specialtybusiness.industryImmunologyCell BiologyHematologyHemarthrosismedicine.diseaseBiochemistryRegimenConcomitantSeverity of illnessmedicineProphylaxis in Factor VII deficiency inherited Factor VII deficiencyObservational studyDosingFresh frozen plasmabusinessBlood
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A Gene-Specific Requirement for FACT during Transcription Is Related to the Chromatin Organization of the Transcribed Region

2006

The FACT complex stimulates transcription elongation on nucleosomal templates. In vivo experiments also involve FACT in the reassembly of nucleosomes traversed by RNA polymerase II. Since several features of chromatin organization vary throughout the genome, we wondered whether FACT is equally required for all genes. We show in this study that the in vivo depletion of Spt16, one of the subunits of Saccharomyces cerevisiae FACT, strongly affects transcription of three genes, GAL1, PHO5, and Kluyveromyces lactis LAC4, which exhibit positioned nucleosomes at their transcribed regions. In contrast, showing a random nucleosome structure, YAT1 and Escherichia coli lacZ are only mildly influenced …

GeneticsChromatin ImmunoprecipitationSaccharomyces cerevisiae ProteinsTranscription GeneticbiologyHigh Mobility Group ProteinsRNA polymerase IIPromoterArticlesSaccharomyces cerevisiaeCell BiologyFACT complexChromatinChromatin remodelingChromatinDNA-Binding ProteinsHistone methylationProtein FACTEscherichia colibiology.proteinTranscriptional Elongation FactorsTranscription factor II DMolecular BiologyRNA polymerase II holoenzymePlasmidsMolecular and Cellular Biology
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Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo

2022

Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…

Olsen 2018Settore ICAR/21 - UrbanisticaSettore M-GGR/01 - GeografiaSacco and Blessi 2009). In the current (post-) pandemic context and through the lens of a southern European perspective the purpose of this article is to critically reflect about the role of culture as possible vehicle of urban and community regeneration. In particular we will focus on the activities of the no profit organization «Laboratorio Zen Insieme» in ZEN2 one of the last large popular and peripheral neighborhoods built in Palermo at the end of 80s in order to explore and understand how cultural practices work as agent of urban and social transformation capable of addressing emerging issues especially in the pandemic scenario we are experiencing. Thecasestudy has been conducted through analysis of documents participative observations (Honer and Hitzler 2015) and qualitative in-depth interviews with key actors involved in the conception organization and management of the activities carried out by Laboratorio Zen Insieme with representatives of local institutions and non-formal conversations with participants of the workshops heldin the neighborhood. The experience we narrate finds that cultural practices have re-conceptualized their design and functions as strategies of urban and community regeneration and at the same time have contributed to answer to emergent issues in developing proximity and local based strategies facing up to problems inherent civil rights educationalpoverty socio-spatial justice and have changed the image and identity of urban places they inhabit.In this sense the research provides a framework for development of strategies and legitimization for cultural practices and a point of discussionabouttheirrolein urban development.Although all cities in the world have been affected by the COVID-19 pandemic its impacts on the territories yet to be understood are unevenly distributed revealing extremely varied imbalances depending on the places. However it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities creating new ones and bringing attention back to those implications between space planning public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and groups a response to the new social and individual needs has been offered by cultural institutions that play a role of territorial agency often independently or in the absence of political institutions. Far from the idea of entertainment and divertissement it is in fact increasingly clear how the practices of cultural innovation experimenting with various forms of action and participation can in some cases play a fundamental role in the processes of social cohesion and community building representing an antidote to the worsening of the phenomena of marginalization and socio-spatial inequalities within cities and territories (Colantonio and Dixon 2011
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Bromodomain factor 1 (Bdf1) protein interacts with histones

2001

AbstractUsing a yeast two-hybrid assay we detected an interaction between the N-terminal region of histone H4 (amino acids 1–59) and a fragment of the bromodomain factor 1 protein (Bdf1p) (amino acids 304–571) that includes one of the two bromodomains of this protein. No interaction was observed using fragments of histone H4 sequence smaller than the first 59 amino acids. Recombinant Bdf1p (rBdf1p) demonstrates binding affinity for histones H4 and H3 but not H2A and H2B in vitro. Moreover, rBdf1p is able to bind histones H3 and H4 having different degrees of acetylation. Finally, we have not detected histone acetyltransferase activity associated with Bdf1p.

Saccharomyces cerevisiae ProteinsRecombinant Fusion ProteinsBiophysicsBromodomainTwo-hybridBiochemistryFungal ProteinsHistonesHistone H4SaccharomycesAcetyltransferasesGenes ReporterStructural BiologyTwo-Hybrid System TechniquesHistone methylationHistone H2AGeneticsHistone acetyltransferase activityHistone octamerMolecular BiologyHistone AcetyltransferasesBromodomain factor 1 proteinbiologyChemistryCell BiologyHistone acetyltransferasePeptide FragmentsChromatinBromodomainHistoneBiochemistryPCAFbiology.proteinHistone acetyltransferaseProtein BindingTranscription FactorsFEBS Letters
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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